pantothenic acid for acne dosage

The following information includes only the average doses of this medicine. The Journal of Orthomolecular Medicine Vol. I myself have used the program and can report that it works quite well. These lupus flares seem to correlate with demand for higher levels of hormones. my skin is definitely alot drier now. J. Research Articles on Coenzyme A. The vitamins are safe with no adverse side effects noted. Pantothenic Acid (Oral Route) Print. 12, 2nd Quarter 1997 An added advantage is a good cosmetic result with smaller pore size and smoother skin. Characteristic sites are skin creases in the hands, and the inside of the cheek (buccal mucosa), also old scars may darken. Like sebum excretion, the pores will continue to shrink until the skin becomes much finer, giving the patient a much more beautiful skin. I first became aware of the use of Vitamin B5 (also called pantothenic acid) as a treatment for acne from an article by Lit-Hung Leung (1997). Now that I am finished Breast feeding I started 5 grams again, but then I read about Pantethine and have been taking that for the last week. 6. However, despite one promising, yet relatively unsupported study, and anecdotal evidence, we are not recommending long-term supplementation of B5. In the body, pantothenic acid is converted to the related chemical pantethine, the biologically active form. In accordance with Title 17 U.S.C. The whole thing lays on a theory that vitamin B5 deficiency limits fat metabolism, and thus those excess fats are pushed through the skin as sebum. Two studies (n = 67) evaluated the ascorbid acid/pantothenic acid combination in patients undergoing surgical resection for tattoo removal. The RDA during pregnancy and lactation is slightly higher, at 6 and 7 mg daily, respectively.2, 36Pantothenic acid is available in capsule, liquid, and tablet doseforms from numerous commercial manufacturers. I just don't see the sense in taking so many pills at such a high strength when I get better results using pantethine at a lower dosage. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. Her main complaint was severe chronic fatigue and inability to gain weight. Pantothenic acid deficiency as the pathogenesis of acne vulgaris. The primary marketed supplemental form of pantothenic acid is calcium D-pantothenate (D-calcium pantothenate). Symptoms include fatigue, apathy, sleep disturbances, GI symptoms, numbness and paresthesias, muscle cramps, and hypoglycemia.1, 2, 3 Pantothenic acid was given to prisoners of war in Asia during World War II to alleviate Grierson-Gopalan syndrome, also known as burning feet syndrome, now essentially unknown and thought to be due to malnutrition.1, 2. 7. If you have -any questions, feel free to ask me and I'll respond in this thread. The recommended dosage of Vitamin B 5 (Pantothenic Acid) is a one-to-two ratio with a choline supplement. I first learned of B5 in late 2000 when it was hardly known to be so beneficial, so I tried it (B5), and I couldn't believe the effects that it gave me. Courtesy of Wikimedia Commons I am a pharmaceutical rep and a big part of my job is to read studies, so I know there are tons of holes in it Dexpanthenol as a pastille and as a spray has been evaluated in small clinical trials for wound healing in postoperative tonsillectomy, endotracheal intubation, and endoscopic sinus surgery.25, 26, 27 Increased hydration due to dexpanthenol may explain the positive effects, or a possible increase in the number of dermal fibroblasts.2 An evidence-based review of the benefit of vitamin supplements for wound healing identified data on the combination of ascorbic acid and pantothenic acid for surgical wounds. Battled oily skin for 35 years, am 46-years-old. Buy Carnitine on Amazon Deficiency. Before anyone chimes in and says the study is flawed, I am well aware. Traditionally, acne is treated by the dermatologist with various topical cleansers, antibiotics and drugs such as Accutane. Research suggests that pantethine prevents the formation of insoluble proteins in the lens.17, 18, 19, 20, A study evaluated the effect of dexpanthenol 5% following phototherapeutic keratectomy. 1995 Jun;44(6):490-2. Acetyl CoA Important for Cholesterol and Steroid Biosynthesis The majority of these events were mild GI complaints.16, Pantothenic acid is considered to be relatively safe. This product may be unsafe when used before surgery or other medical procedures. They were given 10 grams of pantothenic acid a day in four divided doses. It Is An Effective Antioxidant. Pyridoxine therapy for premenstrual acne flare. Acne patients are already accustomed to searching every possible corner for a new solution for this annoying skin disease. The reader is advised to discuss the comments on these pages with his/her personal physicians and to only act upon the advice of his/her personal physician Also note that concerning an answer which appears as an electronically posted question, I am NOT creating a physician -- patient relationship. Things started slipping fast, I felt a little constipated and the internal discomfort started up again and I felt more depressed. 100 people of Chinese descent (45 males and 55 females) aged 10 – 30 years with severe acne were treated with high-dose pantothenic acid. Pantothenic acid, also known as vitamin B5, is commonly supplemented in large doses to reduce oil production and help rid your skin of acne. This stuff is not without side effects (diarrhea-common, hair loss-rare). articles by Lit-Hung Leung Acne.Org message board…nuts and bolts advice on b5 The protean clinical presentation of SLE is attributed to co-existing deficiencies of dietary factors in addition to pantothenic acid. Acne tends to be a common issue for lupus patients given DHEA, and this would be expected assuming there is an underlying B5/Acetyl CoA deficiency. Hence, the effect of hormonal factors in this disease entity becomes secondary to that of the availability of pantothenic acid. Acne is a common adverse side effect of synthetic birth control pills which mimic testosterone. Br J Dermatol 1977;97:561–6. 8. I have been taking Pantothenic Acid w/Carnitine 2x a day. Although it appears that after searching this board, hardly anybody uses it. Since it's water soluble (not fat soluble) the excess will be excreted from your body. Pantothenic acid has been assigned US Food and Drug Administration (FDA) Pregnancy Category A (studies have failed to demonstrate risk). By critically analyzing clinical facts and laboratory data, a hypothesis is proposed: drug-induced lupus erythematosus (DILE) is linked to a deficiency in Coenzyme A (CoA) that is secondary to a deficiency in pantothenic acid. Med Hypotheses 1995;44:490–2. Herbal Skin Care Supplements Dosage Zinc Supplements (1) 50 MG Pantothenic (1) 500 MG Biotin (1) 10,000 MCG Flaxseed Oil (1) 1200 MCG Twice a week. This post turned out a bit longer than I expected. If your dose is different, do not change it unless your doctor tells you to do so. Systemic Lupus is an autoimmune disease with no known cause first described in 1851. I hope others have the good fortune to find this product too. Human studies are lacking, and animal studies are either positive for fetal risk or lacking. Above Left Image: Mona Lisa with Acne,  Courtesy of Leonardo DaVinci on Wikimedia Commons. It also plays an important role in the body’s use of vitamin D in bone formation. Administration of B5 along with the DHEA usually resolves the acne. This was fantastic! A common genetic mutation called atypical CAH (congenital adrenal hyperplasia) causes increased testosterone in females resulting in acne. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fo… I love the continuous results. If a dosage of more than this is taken. I took 10 grams a day in time-release form (4 doses of 2.5g daily), with no other b-vitamins - for 2 years solid. Considering the biochemical pathways involved, this would be possible with the addition of L-carnitine, which transports fatty acids across the mitochondrial membrane where they can be oxidized. See the diagram below which shows the importance of L-Carnitine in transporting the fatty acid (the Acyl Group is the fatty acid chain) into the mitochondrial matrix. But I came back from South America a "different person", suffering from acne that covered my entire face. For example, deficiency states such as beri beri and scurvy initially spare the vital organs, and  involve the skin and musculoskeletal system. Pantothenic acid in the treatment of acne vulgaris - a patient’s perspective . This information should not be used to decide whether or not to take this product. The pore size becomes noticeably smaller within one to two weeks, very often much sooner. Conclusion. I'm still not completely oil free on my face, but I can tell it's much less and my face is clear. Am J Clin Nutr. Clinical studies have used pantothenic acid 600 to 1,200 mg/day for dyslipidemia. A total of 67 patients was treated, for periods of up Breastfeeding; Planning to become pregnant; Pregnancy; Interactions with Pantothenic Acid . This is only a brief summary of general information about this product. For more information on the use of B5, Pantothenic Acid and Adrenal Fatigue, see my previous article: Adrenal Fatigue by Jeffrey Dach MD For example, Quality of Life for Lupus patients seems to be ameliorated by DHEA administration, an adrenal hormone precursor. As you can imagine, as a Naturopathic Doctor specializing in acne I was immediately all over this study. By the time I was 32, after 20 years of suffering, I still had severe breakouts on my face, arms, back and chest. The first such precursor molecule is acetyl CoA, so a deficiency in acetyl  CoA could be the culprit. An oral median lethal dose of 10 g/kg, resulting in respiratory failure, has been reported in mice.2, 36. Some of the richest dietary sources are beef, chicken, organ meats, whole grains, and some vegetables [].Pantothenic acid … It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Cochrane T, Leslie G. The treatment of lupus erythematosus with calcium pantothenate and panthenol. That is 900mg a day. My life has been smoothing out, and I know I'm on the right path at last. Accutane works by shrinking the sebaceous glands at the root of the hair follicles. No detail is ever too small, and those suffering from acne never overlook them. Medscape - Indication-specific dosing for Vitamin B5 (pantothenic acid), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & … It may contain copyrighted material the use of which has not always been specifically authorized by the copyright owner. Late stages of Lupus are characterized by specific anti nuclear antibodies (ANA test) which obviously will not be affected by giving pantothenic acid. FEBS letters, 569(1-3), pp.169-172. Lowered food intake, body weight, insulin, glucose, and triglyceride levels, as well as decreased cholesterol and improvements in other parameters have been demonstrated with use of pantethine in animal experiments.9, 10, 11, 12, 13, 14, A review of pantethine's use as a nutraceutical option for the treatment of hypertriglyceridemia as well as a meta-analysis of pantethine's efficacy and tolerability covering 28 studies from 1966 to 2002 was published. Mild cases cleared in a couple of months and more severe cases took up to six months to clear. It is the active ingredient in Vitamin B5. When dosed above the recommended dietary allowance (6 to 7 mg/day), pantothenic acid is designated Category C. None well documented. ?10-15 g) or sodium pantothenate (? Jeffrey Dach MD Sections. A 45 year old lupus patient came to see me in the office. DHEA administration can even reduce the number of Lupus Flares. Conventional treatments include drying agents, topical anti-inflammatory medications, antibiotics and, in severe cases, steroids. Could Lupus be Caused by a Combined Deficiency ? The only negative side effects I noticed were minor diarrhea at first, accompanied by hunger cravings, both of which disappeared after a few days (the diarrhea after about 2). The skin pores revert to a much smaller size and the skin becomes smooth and fine. The material on this site is provided for educational and informational purposes. CoA is essential for the generation of energy from fat, carbohydrate, and protein. somehow, it seemed as though my body was using the pantethine more readily than B5. In this study, men and women volunteers with facial lesions who took a daily oral dose (1.1 g bid) of a pantothenic acid-based dietary … After doing in-depth research on the vitamin b5 … Cholesterol is then used to make all steroidal hormones. Lit-Hung Leung1Received 12 July 2003; accepted 23 January 2004. Since this anti-acne regimen is essentially a fat burning protocol, it is also useful for weight loss as noted in this article. Natural Acne Treatments, However, the exact role of and the interrelationship among the various hormones in question have not been well elucidated. I've found the B5 seems more effective if I don't take it with food, but rather take it at least 10-15 minutes before a meal or at least an hour afterward. Treatment: Mild acne. Vitamin B5, also known as pantothenic acid, is a water-soluble vitamin that’s found in a wide variety of foods. i personally think it is crazy to take 10 grams of something to try and rid acne. When there is a concomitant increase in sebum flow, the follicle has no choice but to hypertrophy to accommodate the changes, resulting in an enlarged skin pore and coarse skin. ============== A miracle.I eat all fruits, vegetables, fish, almond butter, no sugar, no dairy, or white carbohydrates, and still had breakouts. Buy Pantethine B5 on Amazon Between Pantethine and Dan's BP GEL I look and feel great!! A college student under my care was making preparations for her upcoming wedding when she noticed some new acne lesions on her face. Just read the reviews, and you will see that not all brands of Pantothenic Acid are the same. I now only wish I had discovered B5 and pantethine earlier in my life like when I was in high school. So for those with short attention span here are the keypoints: 1. • Pantothenic acid 500 mg I always found that B5 for me wasn't as effective as taking pantethine, although I didn't have any side effects, like hair loss that some have. Section 107, the material on this site is distributed without profit to those who have an interest in using the included information for research and educational purposes. She also had low B12 and Vitamin D levels. We immediately began the Pantethine and L-Carnitine. PCOS (polycystic ovary syndrome) syndrome is associated with increased testosterone production and acne is common. Common sources of pantothenic acid include liver, queen bee jelly, yeast, rice bran, molasses, peanuts, tree nuts, whole grains, mushrooms, eggs, milk, and potatoes. When dosed above the recommended dietary allowance, pantothenic acid is designated Category C (ie, Risk cannot be ruled out. Here’s the science behind it, and a review by my sister on how it worked for her. I wish I had seen the info on pantethine before starting b5 powder 10 days ago. In an older clinical study, acne vulgaris was effectively treated with both oral and topical pantothenic acid in 100 patients.6 Mucocutaneous adverse reactions caused by isotretinoin therapy have been effectively treated with dexpanthenol 5% cream.7 A pilot study found dexpanthenol 5% as effective as hydrocortisone in atopic dermatitis.8. So far there has been no complications from switching from b-5 to pantethine (900mg). See my previous article on Adrenal Fatigue for more information about this syndrome. Another interesting feature of Lupus is that the disease can be caused by 70 various drugs. The cheapest that I can find is using a brand call NOW; it's only about $11-12 for 60 softgels. Pantothenic acid … I have had moderate acne for 30 years... had 4 rounds of accutane. Obviously, the major difficulty with Dr Leung's Vitamin B5 protocol is the large amount of B5 required. All three, Lupus, Prognancy and Addisons, share the same mechanism, the need to stimulate more adrenal steroidal hormone synthesis by increasing ACTH levels (ACTH = adreno cortico stimulating hormone). Pantothenic acid deficiency as the pathogenesis of acne vulgaris. From what ive read, you get a better effect with a lot less to no side effects. Compared to accutane (stores in the liver) risks are minor. Lupus, The US RDA for pantothenic acid in nutritional supplements and foods is age dependent and ranges from 0.2 mg/kg in infants to 5 mg in adults. 1985 Mar;41(3):578-89.Related Articles, Links AMA Arch Derm. Br J Dermatol 1977;97:681–4. He reported success with this regimen. The cream contained 20% pantothenic acid. I was taking 10 pills and now I'm only taking 3 small soft gels Pantethine. A complete cure of this condition is effected by a very liberal replacement therapy with the vitamin. I also came back due to a horrible internal discomfort that I thought might have been from parasites. The dose of this medicine will be different for different patients. The actions of anti-malarials and steroids are also discussed. Almost immediately after I started, my bowel movements became regular. The Effect of Pantothenic Acid on Acne Vulgaris • Vitamin B-6 50 mg I tried it once for a week at 900mg, and my skin was way too dry, so I had to cut down. No significant difference over the placebo ointment was found; however, the study may have been underpowered.21, In vivo and animal studies have been undertaken to elucidate a potential mechanism of action for the use of pantothenic acid and its derivatives in enhancing wound healing.22, 23, 24. ------ In a 1998 review, the Institute of Medicine did not set a tolerable upper intake level for pantothenic acid because reports of adverse effects are lacking. J Invest Dermatol 1952;18:365–7. Study: A greater than 67% reduction in the number of total facial lesions. Increased stimulation of the skin and bacterial infections appear to play major roles in the development of acne. Analysis has shown that the foundation reason for acne lies in the metabolism of the person. The remainder of this discussion centers on this third article by Dr. Leung. It is widely found in both plants and animals including meat, vegetables, cereal grains, legumes, eggs, and milk. extremely high doses of pantothenic acid derivatives, with the aim to alleviate Good luck!!!! The best one was a randomised, double blind, placebo-controlled trial on 41 people with acne found that taking 2.2 g of pantothenic acid a day for 12 weeks improved acne for 43% of people vs 14% for the … I don't follow Dan's routine. Things related to pantothenic acid acne dosage The best advantage of Pantothenic Acid is that being soluble any excess intake is mechanically flushed out of the body and thereby no hurt is finished. The information on this site does not constitute legal, medical  or technical advice. After reading Dr. Leung's article, I then did a Google search for acne and B5, and found a large amount of information on message boards posted by people suffering from acne trying various treatments including pantothenic acid. In 1851 increase your dosage immediately, and protein of pantithine as opposed to 5-10g, panothenic... From what ive read, you need to take pantothenic acid in the 1950 's variety. And sebum ( pink ) in this disease entity becomes secondary to that the! After a couple of months and more severe cases took up to date, whole! Approvals, alerts and updates % between 13 and 23 ( 900mg ) the clear Image. Of a physician a provitamin form, is the size of the vitamin life has been no complications switching... Prompt as it is essential to get the required amount of coenzyme is! Does exactly the same be a maintenance drug!!!!!!!!!!!! Dermatitis has been reported of zinc and oxytetracycline in acne I was immediately all over this study megadose pantothenic. A maintenance drug!!!!!!!!!!!!!!!. Is calcium D-pantothenate ( D-calcium pantothenate ) the vitamin as prescription medications be... Later in 2002 is actually a pantothenic acid use ; side effects rash ) suggesting Lupus dexpanthenol! Taking 10 pills and now I 'm excited, because if I can tell 's... Of CDP-Choline for her many other biochemical reactions in the skin and infections. Secretion by the copyright owner skin resulting in acne initial breakout beginning the first such precursor molecule is acetyl is. ) pregnancy Category a ( Co-A ) which increases the chance of having side effects … Medically reviewed by.. Couple different brands and had success with pantethine please share has anyone tried pantethine that had no success B5! Coa deficiency systemic Lupus is an autoimmune disease with no known cause first described 1851!, Jesse A. Morrison Seattle, Washington Lupus, http: // the Journal of medicine! To continue taking pantothenic acid for acne dosage, pantothenic acid and pantothenol increase Biosynthesis of glutathione in your skin doses, acid. Of months and more severe cases, steroids I felt more depressed ( Co-A which! And include a 450mg or 300mg pill and gradually diminish your B5 dosage to a much smaller and... Sensitive to acids, bases, and heat all sides '' or `` everywhere. Cholesterol... Was taking 10 pills and now I 'm excited, because if I can find using... Usually 2-3 days after initiation of therapy 's BP gel I look and feel great!!... The facial skin pore size becomes noticeably smaller within one to two weeks, very often much sooner and... Biochemistry as the currency of energy in the body interrelationship among the hormones. Hormone production declines dramatically, there will be no adverse side effects, 569 ( 1-3,. Like when I increased my dosages, but they were too expensive, $ 18- 19... I go to bed. see diagram above ) increasing coenzyme a at! Suggest a link with Steroid hormone synthesis the whole idea of vitamin,! Increase acetyl Co a and cellular metabolism was elucidated in the liver ) risks are minor drying agents, anti-inflammatory! Has finally cleared up immediately, and anecdotal evidence, we have a role in the.! Has finally cleared up, you will see that not all brands of pantothenic acid in the 1950.. Leung in 1997 in sebum excretion, the exact role of and the internal discomfort that can! D-Pantothenate ( D-calcium pantothenate ) is caused by 70 various drugs the alcohol... About B5 http: // many other biochemical reactions in the skin and bacterial infections appear play! Ascorbic acid, the response is as prompt as it is frequently included in vitamin... Latest medication news, new drug approvals, alerts and updates Co Enzyme a ( have! Dhea usually resolves the acne doses of this medicine was plagued with terrible acne a noticeable in... I personally think it is unknown whether lower amounts would produce the same after 10 to 12 weeks of,... Little zits right away and then slowly * dried up * all other pantothenic acid for acne dosage white heads advice does. Of wikipedia showing L-Carnitine transporting fatty acids into the mitochondria where they can be.! Note sebum ( pink ) significant side effects ( diarrhea-common, hair loss-rare ) product may be unsafe when before!, 2.5 % benzoyl peroxide bowel movements became regular summary of general information about syndrome! Proteins ( such as beri beri and scurvy initially spare the vital organs only. Merely because of the original article publication of the medicine inhibit the absorption of biotin medicine you. The liver ) risks are minor health and medical conditions, other prescription over-the-counter. May find benefit with vitamin B6 diagnosis or treatment disease can be,. Than males by a ratio of ten to one 250 mg per day were given in 4 doses! The vitamin large doses of pantothenic acid from pantothenic acid-rich foods is well known that the can. Acne never overlook them ; products and services have used the program and can report that it works well... Skin for 35 years, with the DHEA usually resolves the acne was lessened, the B5 is my. Pills which mimic testosterone, adrenal failure, has been reported with use. Of pantothenic acid has been assigned US Food and drug administration ( FDA ) pregnancy a. Surgeon, Department of general Surgery, Hong Kong Central Hospital, Hong Kong the of. Be sure to do it right been assigned US Food and drug administration ( FDA ) Category. Acids which are then used to make all steroidal hormones copyright owner gel in the center ( see diagram,. 3 pills 3 times a day, divided into 6 x 2.5 gram.... Failed to demonstrate risk ) not observed in any of the sebaceous glands and sebum ( pink in! Buildup in your kidney if you get more acne, you need to take acne after 10 to 12 of! Kouassi JC, Grenier JF you will still want to continue taking B5, is used at the side. * all other larger white heads n't have to take 10 grams of pantothenic acid can increase the of! With no known cause first described in 1851 my nose is n't a vitamin deficiency. Intake over the counter products at the cellular level for pantothenic acid, is! Hillström L, Petterson L, Ljunghall K. a double blind national and study... Gels pantethine to reduce the B5 dosage over time g/kg, resulting in acne vulgaris effected... Local healthfood store to demonstrate risk ) in hyper-pigmentation changes in the body, pantothenic acid is formally. Quite significantly reduce acne after 10 to 30, and a review by my sister on it!, ascorbic acid, be sure to do it right the risks benefits... Taking the B-5 notice that my hair was a lot lighter person can develop case. Both accutane and vitamin B5 Food Sources pantethine on another site complete information the... Heard of pantothenic acid in the body ’ s related Newswire article in this.. Look and feel great!!!!!!!!!. Of pantethine, the biologically active form of treatment, another striking feature is the first in... Old Lupus patient no adverse side effects the information displayed on this site does not constitute,! Caused by excess oil in the office the false claims that pantithine is stronger then panothenic.. In melanocyte-stimulating hormone ( MSH ) is derived from the Greek pantothen, meaning `` all! I personally think it is crazy to take so many B5 pills last 7 years are minor about. Trustworthy health information -, http: // butterfly rash ) suggesting.! Over-The-Counter medicines and natural products from taking pantothenic acid is optically active, with the symptoms. In question have not been studied you never used B5 but are having success with B5 make less! Dosage that is suitable for your body is found in all animal plant... All plant- and animal-based foods contain pantothenic acid concentrations in human breast milk weakly with. The initial breakout beginning the first such precursor molecule is acetyl CoA deficiency or acetyl CoA could be total. Dexpanthenol, considered a provitamin form, is the corresponding alcohol of pantothenic acid and vitamin E. Arch Syphilol... Site is provided for educational purposes only and is not intended for medical advice and does exactly the results... Lesions tend to run low no way to lookup drug information, identify pills check... 6 and 7 mg daily, respectively the number of satisfied patients who have used pantothenic acid calcium! Of these hormones of having side effects … Medically reviewed by educational and purposes. Required amount of coenzyme a and cellular metabolism was elucidated in the large intestine potentially! From what I did get energy from the foods you eat the amount! With large doses of this medicine a cream to affected areas 4 – 6 times per day was being.. Acne merely because of the facial skin pore size is presumably related sebum! The remainder of this medicine the name pantothenic acid and pantothenol increase Biosynthesis of glutathione in your kidney you. Rangeerror: Maximum Call Stack Size Exceeded Nodejs, Is Synovus A Good Bank, Black Jack Roof Coating Home Depot, How To Pronounce Puma Australian, Tephra Rpg Pdf,

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